Lose Weight With Dulaglutide

Dulaglutide is a glucagon-like peptide-1 (GLP-1) medicine for management of type II diabetes mellitus in adults. Trulicity has been shown to help individuals lose weight when combined with diet and exercise lifestyle changes.

If eligible, Alfie providers may prescribe you a form of dulaglutide to help you lose weight.

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What is Dulaglutide? 

Dulaglutide is a Type 1 diabetes medication that has been authorized by the Food and Drug Administration (FDA) for the treatment of diabetes in adults. It's a strong selective GLP-1 receptor agonist that has been found to reduce blood sugar levels and enhance feelings of satiety in people with high BMI. Dulaglutide as brand name Trulicity is one of the weight loss medicines available from an Alfie healthcare provider for weight reduction or a weight-related medical problem. It is manufactured by Eli Lilly.

Dulaglutide should not be taken by individuals with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), in patients with a prior serious hypersensitivity reaction to dulaglutide or to any of the ingredients in dulaglutide, or in patients with a history of pancreatitis.

Brand Name and Class

Dulaglutide is a synthetic peptide that mimics the natural hormone GLP-1 in the body. Dulaglutide works by delaying stomach emptying, making you feel fuller after eating. It also slows down sugar absorption into the circulation, which helps to maintain blood sugar levels within a healthy range. It is available as brand name Trulicity

How it works

GLP-1 is a naturally occurring hormone in the human body that controls hunger and food intake by acting on your brain. Dulaglutide works like GLP-1 to reduce your appetite and how much you eat, allowing you to lose weight.

The GLP-1s in the body promote insulin release after meals to minimize blood sugar levels. They also bind to receptors in the brain that reduce appetite. These receptors generate chemicals that decrease your desire to eat, resulting in weight loss. However, because these molecules are natural substances, they do not stay long in the human body. That is why taking GLP-1s can assist you shed pounds even if your own body produces them naturally.

Is this prescription effective for weight loss? 

Dulaglutide is a safe and effective oral medication that has helped many people lose weight. When compared to persons who took a placebo, dulaglutide was found to be less successful in reducing body weight. An average weight loss of more than 10 pounds occurred when compared with individuals who took a placebo and engaged in greater physical activity.

In studies with other diabetes drugs, weight reduction was typically about 10.1 pounds (4.5 mg). Individual results may vary. In one research, many people lost weight over the course of 6 months, and most were able to maintain their loss for the rest of the study.

How much does dulaglutide cost?

Dulaglutide may be an expensive medication, with an out-of-pocket cost above $1,000. Alfie works with the vast majority of commercial and employer insurance plans in order to get coverage for your doctor-prescribed medication.

Dulaglutide is not covered by Medicare or Medicaid.

How do injection pens work?

Dulaglutide in the form of Trulicity is a medicine that is taken once a week. It's injected under the skin using a simple pen injector syringe, and it's convenient to use. Trulicity injections may be given from the comfort of your own home without the assistance of a medical professional or clinician, and they are easy to use. Trulicity injections are placed directly into the fatty tissue just beneath the skin's surface and should be administered once weekly at the same time each day. You should keep dulaglutide in a refrigerator between 36°F and 46°F.If your doctor prescribes Trulicity, he or she will walk you through the process of injecting it into your belly or upper thigh. Someone else can inject the medicine into your upper arm if you are unable to do it yourself.

If your doctor prescribes dulaglutide, he or she will walk you through the process of injecting it into your belly or upper thigh. Someone else can inject the medicine into your upper arm if you are unable to do it yourself.

Understanding your dosage

GLP-1 injectable medications are offered via a step-up approach, meaning your Alfie healthcare professionals (either an MD or NP) will prescribe a higher dose as your progress through the program until you are at the full dose. This helps minimize the risk of any side effects of taking the medication.

Trulicity comes in 4 different dose strengths. You start Trulicity at a dose of 0.75 mg once daily and increase the dose until you reach the full dose of 4.5 mg. It’ s important to follow the dosing schedule as recommended by your health care provider.

Potential Side Effects

Side effects of dulaglutide are extremely rare and over 95% of individuals who take these medications do not experience side effects. In those that do, nausea or indigestion is often the most common and typically resolves within the first month of being on the medication.

Other common side effects of dulaglutide mediations include nausea, diarrhea, vomiting, constipation, abdominal pain, headache, fatigue, dyspepsia, dizziness, abdominal distention, eructation, hypoglycemia (low blood sugar) in patients with type 2 diabetes, flatulence, gastroenteritis, and gastroesophageal reflux disease. Taking GLP-1 medications may also put you at serious risk of hypoglycemia or acute kidney injury if you are taking another similar medication at the same time.

The GLP-1 class of drugs isn't recommended if you have a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2). They're also not recommended if you've had pancreatitis. If you have any concerns about your family history and ability to take a GLP-1 receptor agonist medication, talk to your primary care provider.

Alternative Medications

Dulaglutide is one of the multiple GLP-1 weight-loss classes of drugs. Other GLP-1 drug classes include:  

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